Maruti Agency is marketing Gemcitabine Injection IP 200 mg in India.
Gemcitabine is S-Phase specific.
It is deoxycytidine antimetabolite.
Gemcitabine gets phosphorylated thrice and gets converted to gemcitabine triphosphate which competes with deoxycytidine triphostate for incorporation into DNA strand.
As the addition of a base pair before DNA polymerase is stopped; Gemcitabine inhibits both DNA repair and replication resulting in apoptosis.